Informatics Publishing Limited

A. A. Attama ¹, J. Obi ², O. N. Ugochukwu ², B. E. Onuigbo ¹

Affiliations
1 Department of Pharmaceutics, University of Nigeria, Nsukka, 410001, NG
2 Department of Science Laboratory Technology, University of Nigeria, Nsukka, NG

Abstract

The cytoprotective effect of four formulations (Batch A, Batch B, Batch C and Batch D) of snail mucin and cimetidine were evaluated using three animal (albino rats) models (indomethacin, histamine and stressinduced ulcer models). Results show that the cytoprotective effect of the formulation variables increased with increase in the concentration of snail mucin extract. The negative control which was Tween 85 had no significant effect on the ulcer (p<0.05). This suggests that a combination of snail mucin and cimetidine in drug delivery may have some therapeutic importance and should be properly harnessed.

Keywords

Peptic Ulcer, Snail Mucin, Cimetidine, Cytoprotective, Animal Models.

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